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Tesamorelin

Tesamorelin (stabilized GHRH(1-44) analog / GHRH receptor agonist peptide) · 5 min read

Tesamorelin is a synthetic 44-amino-acid analog of human growth-hormone-releasing hormone (GHRH(1-44)) bearing a trans-3-hexenoyl modification on the N-terminal tyrosine. In research settings it is handled as a well-characterized peptide reference material (PubChem CID 16137828; CAS 218949-48-5; C₂₂₁H₃₆₆N₇₂O₆₇S; ~5135.86 g/mol) for in-vitro study of GHRH-receptor signaling, peptide-stability chemistry, and analytical identity. This listing is strictly Research Use Only and is not intended for any human or veterinary application.

Analytical identity

Supplied as a lyophilized powder characterized to ≥98% (HPLC). The molecule corresponds to PubChem CID 16137828 (CAS 218949-48-5), with molecular formula C₂₂₁H₃₆₆N₇₂O₆₇S and a reported monoisotopic/average molecular weight near 5135.86 g/mol. Identity and purity are typically confirmed by reversed-phase HPLC and mass spectrometry against the expected sequence and the N-terminal trans-3-hexenoyl modification.

Structure and sequence

The peptide reproduces the full 44-residue sequence of human GHRH(1-44) and carries a trans-3-hexenoyl (C6) acyl group anchored to the N-terminal tyrosine. This N-terminal modification is described in the literature as a structural feature that increases resistance to dipeptidyl-peptidase-mediated cleavage relative to the unmodified peptide, a property of interest in analog-stability and structure-activity chemistry studies.

Mechanism themes in the literature

Research literature characterizes tesamorelin as a GHRH-receptor (GHRHR) agonist. In cell-based and biochemical model systems it is discussed in the context of Gs-coupled adenylyl-cyclase activation and cAMP-dependent signal transduction within somatotrope-axis (GH/IGF-1) pathway models. These mechanism themes are presented for in-vitro investigational context only.

Research context and handling

Used by laboratories as a comparator and reference standard for GHRH-analog receptor-pharmacology assays, peptide-stability experiments, and analytical method development. Store the lyophilized material desiccated and protected from light; consult literature via the PubChem and PubMed references for characterization data. For laboratory research use only — not for human or veterinary use, and not for diagnostic or therapeutic purposes.

Credible sources

Research context only. This article summarizes published in-vitro and pre-clinical research for scientific context. It is not a claim of efficacy or safety and does not constitute medical, usage, or dosing guidance. Helix Reagents products are Research Use Only and not for human or veterinary use.